N-Hydroxysuccinimide (NHS)

N-Hydroxysuccinimide (NHS)

CAS No. 6066-82-6

N-Hydroxysuccinimide (NHS) is a high-purity pharmaceutical and biochemical intermediate extensively used in peptide synthesis, active pharmaceutical ingredient (API) manufacturing, and bioconjugation chemistry. It is widely employed for the preparation of NHS esters that facilitate efficient coupling reactions between carboxyl and amino groups. Owing to its excellent reactivity and stability, NHS is an essential reagent in medicinal chemistry, protein labeling, antibody conjugation, oligonucleotide synthesis, and pharmaceutical research. Manufactured under stringent quality standards, it ensures high purity, excellent batch-to-batch consistency, and reliable performance for laboratory, pilot-scale, and commercial production.

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CAS Number6066-82-6
Molecular FormulaC₄H₅NO₃
Molecular Weight115.09 g/mol
Purity / Assay≥99.0% (HPLC)
AppearanceWhite to Off-White Crystalline Powder
Packaging1 Kg, 5 Kg, 25 Kg HDPE Drum with Double Poly Bag
Storage ConditionsStore in a cool, dry, well-ventilated place. Keep container tightly closed. Protect from moisture and direct sunlight.
HS Code29329990

Applications

Pharmaceutical intermediate Active Pharmaceutical Ingredient (API) synthesis Peptide synthesis NHS ester preparation Amide bond formation Bioconjugation chemistry Antibody–drug conjugate (ADC) synthesis Protein labeling and modification Enzyme immobilization Oligonucleotide synthesis Diagnostic reagent manufacturing Medicinal chemistry Organic synthesis Process development CRO/CDMO custom synthesis Fine chemical manufacturing Specialty chemical production Research & Development (R&D)