PHARMACEUTICAL INTERMEDIATE · HIGH PURITY

4-Fluoro-1-isopropyl-2-methyl-
6-(borolan-2-yl)-1H-benzo[d]imidazole

CAS No. 1231930-37-2

A high-purity benzimidazole boronic acid pinacol ester — an essential building block for Suzuki–Miyaura cross-coupling reactions, API synthesis, and advanced drug discovery programs. Manufactured under rigorous pharmaceutical-grade quality standards.

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Molecular Structure
C₁₅H₂₁BFNO₂ · MW 293.14 g/mol

Chemical Identity

Complete Product Specifications

Every batch tested and certified — analytical reports available on request.

Chemical Identity

IUPAC Name	2-(4-Fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS Number	1231930-37-2
Molecular Formula	C₁₅H₂₁BFNO₂
Molecular Weight	293.14 g/mol
InChI Key	FZXPQNXSXHSOFR-UHFFFAOYSA-N
Common Name	Fluorobenzimidazole Boronic Acid Pinacol Ester

Physical Properties

Appearance	White to off-white crystalline powder
Purity (HPLC)	≥ 98%
Melting Point	98–102 °C (reported)
Solubility	Soluble in DCM, THF, EtOAc, DMSO
Storage	2–8 °C, under inert atmosphere, protected from moisture
Shelf Life	24 months (sealed, dry storage)

Packaging & Supply

Pack Sizes	1 g · 5 g · 25 g · 100 g · Custom
Minimum Order	1 g
Lead Time	In stock — ships within 24–48 hrs
Shipping	Worldwide (DHL, FedEx, courier)
Packaging	HDPE bottle / amber glass vial (N₂ sealed)
COA	Available — issued per batch

Quality & Regulatory

Quality Standard	GMP / ISO 9001
Testing Methods	HPLC, NMR (¹H, ¹³C, ¹¹B), MS, IR
COA	Full analytical CoA per batch
SDS / MSDS	Available on request
Customs	HS Code: 2933.99
Origin	India (Made in India)

Why Choose SRPL

Product Advantages

⚗️

Exceptional Purity ≥ 98%

Each batch is HPLC-verified and backed by a full Certificate of Analysis. Consistent quality lot-to-lot for reproducible research outcomes.

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Suzuki Coupling Ready

The pinacol boronate ester group enables efficient Suzuki–Miyaura cross-coupling reactions — a cornerstone methodology in modern API synthesis.

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Drug Discovery Building Block

Benzimidazole scaffold with fluorine substitution and boronate handle — ideal for generating diverse compound libraries in medicinal chemistry programs.

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Global Supply Capability

Proven export record to pharma companies across EU, USA, Japan, and Southeast Asia. Custom quantities from milligrams to kilograms.

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Full Documentation

CoA, MSDS/SDS, NMR spectra, HPLC chromatograms, and regulatory filing support available for every order.

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Fast Dispatch

In-stock inventory allows same-day processing and worldwide courier delivery within 24–72 hours depending on destination.

Use Cases

Applications & Industries

This versatile intermediate serves across multiple pharmaceutical and chemical research domains.

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API Manufacturing

Used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) for kinase inhibitors, anti-cancer, and antiviral drugs.

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Medicinal Chemistry Research

Enables rapid SAR exploration via C–C bond forming reactions. The fluorine substituent modulates metabolic stability and bioavailability.

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Suzuki–Miyaura Cross-Coupling

Highly efficient Pd-catalyzed coupling partner for aryl/heteroaryl halides, enabling construction of biaryl and heteroaryl frameworks central to drug molecules.

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Drug Discovery & Lead Optimization

Incorporated into combinatorial and fragment-based drug discovery workflows to generate novel chemical entities with improved pharmacokinetic profiles.

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Contract Manufacturing (CMO/CDMO)

Supplied to contract research and manufacturing organizations (CROs/CDMOs) globally for scale-up synthesis of proprietary drug candidates.

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Academic & Industrial Research

Valuable reference compound for catalysis research, reaction methodology development, and structure-activity studies in university and industry labs.

Safety & Handling

Storage & Safety Information

Handle with standard laboratory precautions. Full MSDS/SDS available on request or with every shipment.

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Wear gloves & lab coat

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Use in fume hood

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Store at 2–8 °C

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Keep sealed & dry

⚠️ Handling Advisory: Boronic ester compounds should be handled under inert atmosphere (N₂ or Ar) where moisture sensitivity is a concern. Avoid prolonged skin contact. Follow standard laboratory safety protocols. Dispose of according to local chemical waste regulations.

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CAS 1231930-37-2

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Swapnroop Research Private Limited · India | ISO Certified | GMP Compliant

4-Fluoro-1-isopropyl-2-methyl- 6-(borolan-2-yl)-1H-benzo[d]imidazole